Integrins control migration style
نویسندگان
چکیده
منابع مشابه
Integrins control migration style
anen et al. (page 515) show that  1 and  3 integrins direct different types of motility, despite binding fibro-nectin with similar efficiencies. Cells expressing  1 integrin move in a random manner, whereas cells with  3 integrin expression move in a persistent fashion. The proteins control cell migration by altering the activities of the Rho GTPases RhoA and Rac, which in turn control thre...
متن کاملIntegrins in cell migration.
Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as traction sites. This includes signaling com...
متن کاملEndocytic Trafficking of Integrins in Cell Migration
Integrins are a family of heterodimeric receptors that bind to components of the extracellular matrix and influence cellular processes as varied as proliferation and migration. These effects are achieved by tight spatiotemporal control over intracellular signalling pathways, including those that mediate cytoskeletal reorganisation. The ability of integrins to bind to ligands is governed by inte...
متن کاملIntegrins in cell migration--the actin connection.
The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell...
متن کاملHow integrins control breast biology☆
This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1693iti1